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Synthesis 2002(4): 0483-0486
DOI: 10.1055/s-2002-20960
DOI: 10.1055/s-2002-20960
PAPER
© Georg Thieme Verlag Stuttgart · New York
Regioselective Hydroxylation of 2,4-Lutidine: A Practical Synthesis of 4-Hydroxymethyl-2-methylpyridine
Further Information
Received
13 November 2001
Publication Date:
28 July 2004 (online)
Publication History
Publication Date:
28 July 2004 (online)
Abstract
A practical synthesis of 4-hydroxymethyl-2-methylpyridine has been developed which makes use of Evans’ regioselective lithiation of readily available 2,4-lutidine and trapping with dimethylformamide.
Key words
lithiation - hydroxylation - regioselectivity - pyridines
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