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DOI: 10.1055/s-2002-21568
Copyright © 2002 by Thieme Medical Publishers, Inc., 333 Seventh Avenue, New York, NY 10001, USA. Tel.: +1(212) 584-4662
Recurrent Giant Cell Reparative Granuloma of the Skull Base and the Paranasal Sinuses Presenting with Acute One-Sided Blindness
Publication History
Publication Date:
18 May 2004 (online)
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ABSTRACT
The etiology, pathogenesis, histopathologic diagnosis, prognosis, and treatment of giant cell reparative granulomas of the skull are controversial. We report a 14-year-old girl with an advanced recurrent giant cell reparative granuloma of the skull base and paranasal sinuses whose only clinical manifestation was a loss of vision. After undergoing endovascular catheter embolization, the patient underwent repeated surgical resections of the mass via a combined frontobasal and modified infratemporal approach followed by radiation therapy. Histopathologic examination confirmed the diagnosis of giant cell reparative granuloma. A traumatic event in the patient's history-a fossa canina abscess followed by tooth extraction 14 months before admission-supports the theory of a reactive reparative process as a pathogenetic mechanism for this disease. Histopathologic criteria and clinical aggressiveness must be considered to achieve adequate treatment of giant cell lesions of the skull.
KEYWORD
Giant cell reparative granulomas - giant cell tumor - skull base
REFERENCES
- 1 Schajowicz F, Sissons H A, Sobin L H. The World Health Organization's histologic classification of bone tumors: a commentary on the second edition. Cancer . 1995; 75 1208-1214
- 2 Tallan E M, Olsen K D, McCaffrey T V, Unni K K, Lund B A. Advanced giant cell granuloma: a twenty-year study. Otolaryngol Head Neck Surg . 1994; 110 413-418
- 3 Jaffe H L. Giant-cell reparative granuloma, traumatic bone cyst, and fibrous (fibroosseus) dysplasia of the jaw bones. Oral Surg . 1953; 6 159-175
- 4 Rhea J T, Weber A L. Giant cell tumor of the sinuses. Radiology . 1983; 147 135-137
- 5 Dahlin D C. Bone Tumors: General Aspects and Data on 8,542 Cases, 4th ed. Springfield, Il: Charles C Thomas; 1986: 119-140
- 6 Katz A, Hirschl S. Giant cell reparative granuloma in the temporal bone. Arch Otolaryngol . 1974; 100 380-382
- 7 Lewis M L, Weber A L, McKenna M J. Reparative cell granuloma of the temporal bone. Ann Otol Rhinol Laryngol . 1994; 103 826-828
- 8 Ung F, Li K K, Keith D A, McKenna M J. Giant cell reparative granuloma of the temporal bone: case report and review of the literature. Otolaryngol Head Neck Surg . 1998; 118 525-529
- 9 Friedberg S A, Eisenstein R, Wallner L J. Giant cell lesions involving the nasal accessory sinuses. Laryngoscope . 1969; 79 763-776
- 10 Wiatrak B J, Gluckmann J L, Fabian R L, Wesseler T A. Giant cell reparative granuloma of the ethmoid sinus. Otolaryngol Head Neck Surg . 1987; 97 504-509
- 11 Ciapetta P, Salvati M, Bernardi C, Raco A, Di Lorenzo N. Giant cell reparative granuloma of the skull base mimicking an intracranial tumor. Surg Neurol . 1990; 33 52-56
- 12 Hoopes P C, Anderson R L, Blodi F C. Giant cell (reparative) granuloma of the orbit. Ophthalmology. . 1981; 88 1361-1366
- 13 Hirschl S, Katz A. Giant cell reparative granuloma outside the jaw bone: diagnostic criteria and review of the literature with the first case described in the temporal bone. Hum Pathol . 1974; 5 171-181
- 14 Lorenzo J C, Dorfman H D. Giant-cell reparative granuloma of the short tubular bones of the hands and feet. Am J Surg Pathol . 1980; 4 551-563
- 15 Wold L E, Dobyns J H, Swee R G, Dahlin D C. Giant cell reaction (giant cell reparative granuloma) of the small bones of the hands and feet. Am J Surg Pathol . 1986; 10 491-496
- 16 Schulz A, Maerker R, Delling G. Das zentrale Riesenzellgranulom. Histochemische und ultrastrukturelle Untersuchungen zur Histiogenese. Virchows Arch A Pathol Anat Histol . 1976; 371 161-170
- 17 Batsakis J G. Tumors of the head and neck: clinical and pathological considerations, 2nd ed. Baltimore, MD: Williams & Wilkins 1979: 395-419
- 18 Colclasure J B, Shea M J, Graham S S. Giant cell lesions of the temporal bone. Am J Otol . 1981; 2 188-192
- 19 Chuong R, Kaban L B, Kozakewich H, Perez-Atayde A. Central giant cell lesions of the jaws: a clinicopathologic study. J Oral Maxillofac Surg . 1986; 44 708-713
- 20 Weber A L, Hug E B, Muenter M W, Curtin H D. Giant-Cell tumors of the sphenoid bone in four children: radiological, clinical and pathological findings. Skull Base Surgery . 1997; 4 163-173
- 21 Adler C P. Bone Diseases. Berlin: Springer; 2000: 204
- 22 Auclair P L, Cuenin P, Kratochvil F J, Slater L J, Ellis G L. A clinical and histomorphologic comparison of the central giant cell granuloma and the giant cell tumor. Oral Surg . 1988; 66 197-208
- 23 Eisenbud L, Stern M, Rothberg M, Sachs S A. Central giant cell granuloma of the jaws: experience in management of thirty-seven cases. J Oral Maxillofac Surg . 1988; 46 376-384
- 24 Saleh E A, Taibah A K, Naguib M, Aristegui M, Vassallo G, Landolfi M, Sanna M. Giant cell tumor of the lateral skull base: a case report. Otolaryngol Head Neck Surg . 1994; 111 314-318