Recurrent Giant Cell Reparative Granuloma of the Skull Base and the Paranasal Sinuses Presenting with Acute One-Sided Blindness

Stefan K.-R. Plontke; Claus-Peter Adler; Jan Gawlowski; Ulrike Ernemann; Sigrid A. Friese; Peter K. Plinkert

doi:10.1055/s-2002-21568

Skull Base, Table of Contents

Skull Base 2002; 12(1): 009-018
DOI: 10.1055/s-2002-21568

CASE REPORT

Recurrent Giant Cell Reparative Granuloma of the Skull Base and the Paranasal Sinuses Presenting with Acute One-Sided Blindness

Stefan K.-R. Plontke¹ , Claus-Peter Adler⁴ , Jan Gawlowski² , Ulrike Ernemann³ , Sigrid A. Friese³ , Peter K. Plinkert⁵

¹Department of Otorhinolaryngology: Head and Neck Surgery, University of Tubingen, Tubingen, Germany
²Department of Neurosurgery, University of Tubingen, Tubingen, Germany
³Department of Neuroradiology/Interventional Radiology, University of Tubingen, Tubingen, Germany
⁴Department of Pathology, Reference Center of Bone Diseases, University of Freiburg, Freiburg, Germany
⁵Department of Otorhinolaryngology: Head and Neck Surgery, University of Saarland, Homburg/Saar, Germany

Abstract

ABSTRACT

The etiology, pathogenesis, histopathologic diagnosis, prognosis, and treatment of giant cell reparative granulomas of the skull are controversial. We report a 14-year-old girl with an advanced recurrent giant cell reparative granuloma of the skull base and paranasal sinuses whose only clinical manifestation was a loss of vision. After undergoing endovascular catheter embolization, the patient underwent repeated surgical resections of the mass via a combined frontobasal and modified infratemporal approach followed by radiation therapy. Histopathologic examination confirmed the diagnosis of giant cell reparative granuloma. A traumatic event in the patient's history-a fossa canina abscess followed by tooth extraction 14 months before admission-supports the theory of a reactive reparative process as a pathogenetic mechanism for this disease. Histopathologic criteria and clinical aggressiveness must be considered to achieve adequate treatment of giant cell lesions of the skull.

KEYWORD

Giant cell reparative granulomas - giant cell tumor - skull base

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References

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