Planta Med 2002; 68(3): 258-261
DOI: 10.1055/s-2002-23125
Original Paper
Natural Product Chemistry
© Georg Thieme Verlag Stuttgart · New York

Bisxanthones from Hypericum japonicum: Inhibitors of PAF-Induced Hypotension[*]

Kyoko Ishiguro1 , Satoko Nagata1 , Hisae Oku1 , Masae Yamaki1
  • 1School of Pharmaceutical Sciences, Mukogawa Women's University, Koshien Kyuban-cho, Hyogo, Japan
Weitere Informationen

Publikationsverlauf

May 10, 2001

June 4, 2001

Publikationsdatum:
25. März 2002 (online)

Abstract

The CHCl3-soluble part (HJ) of the MeOH extract from Hypericum japonicum afforded new bisxanthones, jacarelhyperols A (1) and B (2). The structures were elucidated by spectral methods. These compounds and HJ showed significant inhibitory effects against PAF-induced hypotension by an in vivo evaluation method, which can reveal the pharmacological action of the test material.

Abbreviations

PAF:platelet-activating factor

HEL:hen egg-white lysozyme

CV 3988:rac-3-(N-n-octadecyl carbamoyloxy)-2-methoxypropyl2-thiazoliethyl phosphate

1 * Part 10 in the series; for part 9 see ref. [3].

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1 * Part 10 in the series; for part 9 see ref. [3].

Dr. Kyoko Ishiguro

School of Pharmaceutical Sciences

Mukogawa Women's University

Koshien Kyuban-cho

Nishinomiya

Hyogo 663-8179

Japan

eMail: ishiguro@mwu.mukogawa-u.ac.jp

Fax: +81 798-41-2792