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Aktuelle Dermatologie 2002; 28(3): 96-99
DOI: 10.1055/s-2002-25238
Originalarbeit
© Georg Thieme Verlag Stuttgart · New York

Pflaster statt Messer - neue Therapie des Basalioms mit 5-Fluorouracil?

Plaster Instead of Knife - New Therapy of Basal Cell Carcinoma with 5-Fluorouracil?Christiane  Bayerl1 , D.  Siebold1 , M.  Fuchslocher1 , E.  G.  Jung1
  • 1Klinik für Dermatologie, Venerologie und Allergologie Mannheim, Universitätsklinik Mannheim
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Publication History

Publication Date:
19 April 2002 (online)

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Zusammenfassung

Das Basaliom ist der häufigste epitheliale Hauttumor des Menschen und wird zumeist chirurgisch behandelt. Wir stellen drei Kasuistiken zur lokalen Behandlung histologisch gesicherter Basaliome mit 5-Fluorouracil in einem transdermalen System vor, das täglich erneuert wird. Die Behandlung war sicher und effektiv, wie die Biopsien und die Kontrollen bis 6 Monate nach Therapieende zeigten. Eine Irritation der Haut trat nicht auf. Die kosmetischen Ergebnisse waren hervorragend. Daher haben wir eine klinische Studie geplant, um die Effekte des 5-Fluorouracil-Pflasters als neue Therapieoption für das Basaliom zu überprüfen.

Abstract

Basal cell carcinoma is the most frequent non-melanoma skin cancer in humans, treated mostly surgically. We present three case reports about topical application of 5-fluorouracil in a transdermal delivery system applied daily on histologically proven basal cell carcinomas. The treatment was safe and effective, shown by biopsies and follow-up for 6 months. Irritative effects were not seen. The cosmetic results were excellent. According to this, we will perform a controlled study to evaluate if 5-fluorouracil plaster might be a new treatment option for basal cell carcinoma.

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PD Dr. med. Christiane Bayerl

Klinik für Dermatologie, Venerologie und Allergologie Mannheim · Universitätsklinik

Theodor-Kutzer-Ufer 1 - 3 · 68135 Mannheim ·

Email: christiane.bayerl@haut.ma.uni-heidelberg.de