A Mild Deprotection of Trichloroethyl Carbamates Using Indium Metal

Tomoko Mineno; Seoung-Ryoung Choi; Mitchell A. Avery

doi:10.1055/s-2002-31919

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Synlett 2002(6): 0883-0886
DOI: 10.1055/s-2002-31919

LETTER

A Mild Deprotection of Trichloroethyl Carbamates Using Indium Metal

Tomoko Mineno^a, Seoung-Ryoung Choi^a, Mitchell A. Avery*^a-c
Department of Medicinal Chemistry, School of Pharmacy, University of Mississippi, P.O. Box 1848, University, MS 38677-1848, USA
Department of Chemistry, University of Mississippi, P.O. Box 1848, University, MS 38677-1848, USA
National Center for Natural Products Research, University of Mississippi, P.O. Box 1848, University, MS 38677-1848, USA
Fax: +1(662)9155638; e-Mail: mavery@olemiss.edu;

Further Information

Publication History

Received 20 March 2002
Publication Date:
07 February 2007 (online)

Abstract
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Abstract

The trichloroethoxycarbonyl moiety was efficiently removed from carbamates to furnish the corresponding amines using indium metal in good to excellent yields.

Key words

indium - deprotection - amines - 2,2,2-trichloroethyl carbamates - chemoselectivity

References

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Aldrich Chemical Company. Indium powder, 99.99%. Catalog # 27,795-9.