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Synlett 2002(7): 1065-1068
DOI: 10.1055/s-2002-32603
DOI: 10.1055/s-2002-32603
LETTER
© Georg Thieme Verlag Stuttgart · New York
A Concise Route to the Key Intermediate of (+)-Vernolepin Using A Bicyclo[3.2.1]octane Chiral Building Block
Further Information
Received
26 April 2002
Publication Date:
07 February 2007 (online)
Publication History
Publication Date:
07 February 2007 (online)
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Abstract
An enantioselective route to the key intermediate leading to (+)-vernolepin, an antitumor sesquiterpene, isolated from Vernonia hymenolepis, has been developed starting from the chiral building block having a bicyclo[3.2.1]octane framework accessible by either enzymatic or catalytic kinetic resolution.
Key words
chiral building block - convex-face stereoselection - (+)-vernolepin precursor - antitumor sesquiterpene - bicyclo[3.2.1]octenone
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References
Miyazawa, N.; Tosaka, A.; Hanada, K.; Ogasawara, K. to be published.