Synlett 2002(7): 1065-1068
DOI: 10.1055/s-2002-32603
LETTER
© Georg Thieme Verlag Stuttgart · New York

A Concise Route to the Key Intermediate of (+)-Vernolepin Using A Bicyclo[3.2.1]octane Chiral Building Block

Norio Miyazawa, Kunio Ogasawara*
Pharmaceutical Institute, Tohoku University, Aobayama, Sendai 980-8578, Japan
Fax: +81(22)2176845; e-Mail: konol@mail.cc.tohoku.ac.jp;
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Publikationsverlauf

Received 26 April 2002
Publikationsdatum:
07. Februar 2007 (online)

Abstract

An enantioselective route to the key intermediate leading to (+)-vernolepin, an antitumor sesquiterpene, isolated from Vernonia hymenolepis, has been developed starting from the chiral building block having a bicyclo[3.2.1]octane framework accessible by either enzymatic or catalytic kinetic resolution.

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Miyazawa, N.; Tosaka, A.; Hanada, K.; Ogasawara, K. to be published.