Zusammenfassung
Das Grundprinzip der transkraniellen Magnetstimulation (TMS) besteht in der Modulation der kortikalen Erregbarkeit mit netto-inhibierenden oder netto-fazilitierenden Effekten. Damit eröffnet sich ein weites Feld der Förderung adaptiver und Hemmung maladaptiver Reorganisationsvorgänge des Gehirns. Einer Reihe viel versprechender Ansätze zur Beeinflussung von neurologischen Defiziten nach Gehirninfarkt stehen zur Zeit nur wenige gesicherte oder klinisch direkt umsetzbare Anwendungen gegenüber. Dies könnte sich aber in absehbarer Zeit ändern. Erste positive Ergebnisse bei Patienten werden zur Zeit in größeren randomisierten und plazebokontrollierten Studien überprüft.
Abstract
The basic principle of transcranial magnetic stimulation (TMS) is modulation of cortical excitability, with either net-inhibitory or net-facilitatory effects. TMS offers new therapeutic options to support adaptive or inhibit maladaptive reorganization in the brain. A number of promising approaches for modulation of neurological deficits after stroke exist, but few have been thoroughly evaluated. There are, however, promising positive results observed in single case studies. These results are presently evaluated in randomized and placebo-controlled clinical trials.
Key words
Transcranial magnetic stimulation - Stroke - Therapy
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Dr. med. A. Flöel
Klinik und Poliklinik für Neurologie · Universitätsklinikum Münster
Albert-Schweizer-Straße 33
48149 Münster
