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DOI: 10.1055/s-2002-32903
ent-Trachyloban-3β-ol, a New Cytotoxic Diterpene from Croton zambesicus
Publikationsverlauf
Received: October 22, 2001
Accepted: February 24, 2002
Publikationsdatum:
22. Juli 2002 (online)
![](https://www.thieme-connect.de/media/plantamedica/200207/lookinside/thumbnails/10.1055-s-2002-32903-1.jpg)
Abstract
The dichloromethane extract of leaves of Croton zambesicus (Euphorbiaceae) showing in vitro cytotoxicity against human cervix carcinoma cells was investigated in order to identify its active compounds. A bio-guided fractionation by HSCCC followed by MPLC led us to isolate a trachylobane diterpene, ent-trachyloban-3β-ol, with cytotoxic properties (IC50 on HeLa cells = 7.3 μg/ml) . This is the first report on the cytotoxicity of a trachylobane diterpene.
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Sébastien Block
Laboratoire de pharmacognosie
Unité CHAM
UCL 72.30
Avenue E. Mounier 72
1200 Bruxelles
Belgium
eMail: sebastien.block@cham.ucl.ac.be
Fax: +32 2 764.72.53