A Facile Access to 2-CF3-Imidazo[1,2-a]pyridines

Arcady L.  Krasovsky; Valentine G.  Nenajdenko; Elizabeth S.  Balenkova

doi:10.1055/s-2002-33106

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Synthesis 2002(10): 1379-1384
DOI: 10.1055/s-2002-33106

PAPER

A Facile Access to 2-CF₃-Imidazo[1,2-a]pyridines

Arcady L. Krasovsky, Valentine G. Nenajdenko*, Elizabeth S. Balenkova
Department of Chemistry, Moscow State University, 119899 Moscow, Russia
Fax: +7(095)9328846; e-Mail: Nen@acylium.chem.msu.ru;

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Publication History

Received 10 April 2001
Publication Date:
01 August 2002 (online)

Abstract
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Abstract

A new simple and efficient way to 2-CF₃-imidazo[1,2-a]pyridines and 2-CF₃-imidazo[1,2-a]quinolines by the reaction of 1,1,1-trifluoro-4-(phenylsulfonyl)but-3-ene-2,2-diols 1a,b with various 2-aminopyridines is described. The cyclization reaction proceeds diastereospecifically under mild conditions in water.

Key words

diastereoselectivity - cycloaddition - heterocycles - imidazo[1,2-a]pyridines - imidazo[1,2-a]quinolines - sulfones

References

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