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Synthesis 2002(11): 1505-1508
DOI: 10.1055/s-2002-33330
PAPER
© Georg Thieme Verlag Stuttgart · New York

Organic Reactions in Ionic Liquids: Ionic Liquid-Accelerated
Cyclocondensation of α-Tosyloxyketones with 2-Aminopyridine

Yuan-Yuan Xieb, Zhen-Chu Chen*a,b, Qin-Guo Zhengc
a Ningbo Institute of Technology, Zhejiang University, Ningbo, 315104, P. R. China
b Department of Chemistry, Zhejiang University (Xi-Xi campus), Hangzhou, 310028, P. R. China
e-Mail: zhenchuc@mail.hz.zj.cn;
c Pharmaceutical Sciences Research Institute, Aston University, Aston Triangle, Birmingham B4 7ET, UK
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Publication History

Received 6 February 2002
Publication Date:
23 August 2002 (online)

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Abstract

The room temperature ionic liquid n-butylpyridinium tetrafluoroborate (BPyBF4) is used as a ‘green’ recyclable alternative to classical molecular solvents for the cyclocondensation of α-tosyloxyketones with 2-aminopyridine. Significant rate enhancements and improved yields have been observed.

Key words

ionic liquid - 2-aminopyridine - α-tosyloxyketones - cyclocondensation