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Synthesis 2002(13): 1804-1806
DOI: 10.1055/s-2002-33906
DOI: 10.1055/s-2002-33906
SHORTPAPER
© Georg Thieme Verlag Stuttgart · New York
Tetrabutylammonium Peroxydisulfate in Organic Synthesis; XIII. [1] A Simple and Highly Efficient One-Pot Synthesis of Nitriles by Nickel-Catalyzed Oxidation of Primary Alcohols with Tetrabutylammonium Peroxydisulfate
Weitere Informationen
Received
30 April 2002
Publikationsdatum:
09. September 2002 (online)
Publikationsverlauf
Publikationsdatum:
09. September 2002 (online)
![](https://www.thieme-connect.de/media/synthesis/200213/lookinside/thumbnails/10.1055-s-2002-33906-1.jpg)
Abstract
A facile one-pot method is presented for the synthesis of nitriles from the corresponding primary alcohols by nickel-catalyzed oxidation with tetrabutylammonium peroxydisulfate in the presence of ammonium hydrogen carbonate under basic aqueous conditions. This convenient synthetic method provides an easy and simple access to various aliphatic, aromatic and heterocyclic nitriles in excellent yields with very high purity.
Key words
tetrabutylammonium peroxydisulfate - nitriles - primary alcohols - oxidation
Part XII: Chen, F. E.; Lu Y. W.; He, Y. P.; Luo, Y. F.; Yan, M. G. Synth. Commun. 2002, in press.
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Part XII: Chen, F. E.; Lu Y. W.; He, Y. P.; Luo, Y. F.; Yan, M. G. Synth. Commun. 2002, in press.