Die Wächterlymphknotenbiopsie wird weltweit als grundsätzliche Methode des nodalen Stagings bei Melanom angesehen. Inzwischen wird allgemein akzeptiert, dass ein positiver Wächterlymphknotenbefund der wichtigste prognostische Faktor für das Gesamtüberleben darstellt. Die entscheidende Frage dieser Methode ist jedoch, ob das diagnostische Verfahren Wächterlymphknotenbiopsie gefolgt ist von einem therapeutischen Nutzen für die Patienten. Diese Frage wird zur Zeit in verschiedenen Studienkonzepten der USA und Deutschlands überprüft.
Abstract
Sentinel lymph node biopsy is regarded world-wide as the principal staging method for melanoma. Meanwhile it is commonly accepted that a positive sentinel lymph node is the most important prognostic factor for overall survival. The crucial question for this method, however, is whether the diagnostic procedure sentinel lymph node biopsy is followed by a therapeutical benefit for the patients. These questions are at present answered in randomized multicentre clinical trials in the USA and Germany.
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