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Planta Med 2002; 68(9): 818-821
DOI: 10.1055/s-2002-34408
Original Paper
Natural Product Chemistry
© Georg Thieme Verlag Stuttgart · New York

Cardioactive Diterpenes from the Roots of Salvia eriophora

Ayhan Ulubelen1 , Hüsniye Birman2 , Sevil Öksüz1 , Gülaçtı Topçu1, 3 , Ufuk Kolak1 , Aslı Barla1 , Wolfgang Voelter4
  • 1University of Istanbul, Faculty of Pharmacy, Department of Chemistry, Istanbul, Turkey
  • 2University of Istanbul, Faculty of Medicine, Department of Physiology, Istanbul, Turkey
  • 3TUBITAK, Marmara Research Center, Materials & Chemical Technologies Research Institute, Gebze, Kocaeli, Turkey
  • 4University of Tübingen, Physiological Institute, Department of Physical Biochemistry, Tübingen, Germany
Further Information

Publication History

Received: December 4, 2001

Accepted: April 21, 2002

Publication Date:
30 September 2002 (online)

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Abstract

From the roots of Salvia eriophora (Lamiaceae), a new compound, 4,14-dihydroxysaprorthoquinone, was isolated in addition to ten known diterpenoids. The structure of the new compound was established by spectroscopic analysis. The crude extract of the plant and the isolated diterpenoids were tested for their cardiovascular activities using Wistar Albino rats. Activity was demonstrated in the crude extract and in 4,14-dihydroxysaprorthoquinone, aethiopinone, ferruginol, 4,12-dihydroxysapriparaquinone, and 6,7-dehydroroyleanone.

Key words

Salvia eriophora - Lamiaceae - abietane and rearranged abietane diterpenes - vasodepressor effect

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Prof. Dr. Ayhan Ulubelen

Faculty of Pharmacy

University of Istanbul

34452 Beyazıt-Istanbul

Turkey

Fax: +90212-5190812

Email: aulubelen@yahoo.com