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Horm Metab Res 2002; 34(9): 492-498
DOI: 10.1055/s-2002-34788
DOI: 10.1055/s-2002-34788
Original Clinical
© Georg Thieme Verlag Stuttgart · New YorkObesity and Weight Gain Are Associated with Increased Incidence of Hyperinsulinemia in Non-Diabetic Men
Further Information
Publication History
Received: 18 September 2001
Accepted after revision: 23 April 2002
Publication Date:
17 October 2002 (online)
Abstract
We investigated the temporal relationships between obesity, weight change and hyperinsulinemia in a population-based 4-year follow-up study of 695 middle-aged, non-diabetic, and normoinsulinemic men. Thirty-eight men developed hyperinsulinemia during the follow-up (fasting serum insulin ≥ 12.0 mU/l). In logistic regression analysis adjusting for other risk factors, men with body mass index of ≥ 26.7 kg/m2 (highest third) had a 6.6-fold (p = 0.001) risk of developing hyperinsulinemia, compared with men with body mass index of < 24.4 kg/m2 (lowest third). Correspondingly, men with waist-to-hip ratio of ≥ 0.95 (highest third) had a 3.5-fold (p = 0.028) incidence of hyperinsulinemia compared with men with waist-to-hip ratio of < 0.90 (lowest third). Weight gain in middle age and weight gain from the age of 20 years to middle age were also associated with increased risk of hyperinsulinemia. Hyperinsulinemia at baseline was not associated with weight gain during the follow-up. This prospective population-based study emphasizes the importance of avoiding obesity and weight gain during adulthood in preventing hyperinsulinemia.
Key words
Obesity - Weight Gain - Hyperinsulinemia - Insulin Resistance - Population Studies - Cohort Study
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H.-M. Lakka, M.D., Ph.D.
Human Genomics Laboratory, Pennington Biomedical Research Center ·
Louisiana State University · 6400 Perkins Road, Baton Rouge · Louisiana 70808-4124
· USA
Phone: + 1 (225) 763 2631
Fax: + 1 (225) 763 3166
Email: lakkah@pbrc.edu