Abstract
Seven lignans from Schisandra chinensis were investigated for their inhibitory activity on NFAT transcription. Both gomisin N (IC50 : 1.33 ± 0.05 μM) and schisandrol A (IC50 : 1.34 ± 0.05 μM) showed higher activity than gomisin E (IC50 : 4.73 ± 0.09 μM), schisandrin A (IC50 : 7.23 ± 0.21 μM), schisandrin C (IC50 : 7.54 ± 0.22 μM), benzoylisogomisin O (IC50 : 11.06 ± 1.02 μM) and schisandrol B (IC50 : 16.37 ± 1.00 μM).
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Young Ho Kim, Ph. D.
College of Pharmacy
Chungnam National University
Daejeon, 305-764, Korea
Phone: +82-42-821-5933
Fax: +82-42-823-6566
Email: yhk@cnu.ac.kr
