Synthesis of β-Amino and β-Hydroxy Phosphonates

Natalia N. Sergeeva; Alexander S. Golubev; Lothar Hennig; Klaus Burger

doi:10.1055/s-2003-38688

PAPER

Synthesis of β-Amino and β-Hydroxy Phosphonates

Natalia N. Sergeeva^a, Alexander S. Golubev^b, Lothar Hennig^a, Klaus Burger*^a
^a Department of Organic Chemistry, University of Leipzig, Johannisallee 29, 04103 Leipzig, Germany
Fax: +49(341)9736599; e-Mail: burger@organik.chemie.uni-leipzig.de;
^b Institute of Organoelement Compounds, Russian Academy of Sciences, Vavilov Str. 28, GSP-1, V-334 RUS, 117813 Moscow, Russia

Abstract

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Abstract

Two alternative routes to methyl and trifluoromethyl substituted β-amino and β-hydroxy phosphonates via hydrogenation of vinylphosphonates and via aldol-type addition of ethylphosphonate to trifluoromethyl substituted imines and carbonyl compounds are described.

Key Words

hydrogenation - aldol reactions - fluorinated imines - fluorinated ketones - phosphonates

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Referenzen

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