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DOI: 10.1055/s-2003-38875
© Georg Thieme Verlag Stuttgart · New York
Three New Jatrophane-Type Diterpenes from Euphorbia pubescens
Publikationsverlauf
Received: August 5, 2002
Accepted: November 23, 2002
Publikationsdatum:
23. April 2003 (online)
![](https://www.thieme-connect.de/media/plantamedica/200304/lookinside/thumbnails/10.1055-s-2003-38875-1.jpg)
Abstract
Three new macrocyclic jatrophane diterpene polyesters, named pubescenes A (1), B (2), and C (3), and the known compounds indole-3-aldehyde and scopoletin have been isolated and characterised from the whole dried plant of Euphorbia pubescens. The structures of the new compounds were established by spectroscopic means including 2D-NMR techniques such as COSY, HMQC, HMBC and NOESY experiments. Compounds 1 - 3 were evaluated for their in vitro effect on the growth of three human cancer cell lines MCF-7 (breast), NCI-H460 (lung) and SF-268 (CNS) as well as for their capacity to interfere with the proliferation of human peripheral blood lymphocytes. They exhibited a moderate growth inhibitory effect on the cancer cell line NCI-H460. No effect was observed on the mitogenic response of human lymphocytes to PHA.
Key words
Euphorbia pubescens - Euphorbiaceae - jatrophane diterpenes - antitumour
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Prof. Maria José Umbelino Ferreira
Centro de Estudos de Ciências Farmacêuticas
Faculdade de Farmácia da Universidade de Lisboa
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