Zusammenfassung
An der Entstehung von Angsterkrankungen sind neben psychosozialen auch genetische Faktoren beteiligt. Klinische Studien haben insbesondere Hinweise auf einen Beitrag genetischer Faktoren zur Entstehung der Panikstörung von ungefähr 48 % erbracht. Für Panikstörung, aber auch für andere Angsterkrankungen gibt es erste molekulargenetische Befunde. Diese Befunde könnten die Grundlage für neue Therapieansätze liefern.
Summary
Psychosocial as well as genetic factors contribute to the pathogenesis of anxiety disorders. Clinical studies have in particular provided evidence for a genetic liability to panic disorder of about 48 %. Evidence for the association of genes with panic disorder, but also with other anxiety disorders has been reported. These findings may provide the basis for the development of innovative therapies.
Key Words
anxiety disorders - panic disorder - heritability - association studies - monoamine oxidase A - intermediate phenotypes
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Korrespondenzadresse:
PD Dr.med. J Deckert
Klinik und Poliklinik für Psychiatrie und Psychotherapie
Universitätsklinikum Münster
Albert-Schweitzer-Str. 11
48149 Münster
eMail: deckertj@uni-muenster.de
