Effective Fluorination Reaction with Et₃N˙3HF Under Microwave Irradiation

Abstract

Fluorination reaction of epoxides and alkyl mesylates can be effectively achieved by reaction with Et₃N˙3HF under microwave irradiation. The reaction time could be greatly reduced compared to the reaction under thermal conditions. The reactions were completed in a few minutes and the use of large excess of reagents could be avoided.

Key words

microwave irradiation - epoxides - fluorination - ring opening - Et₃N˙3HF

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