Nonspecific colonic ulcers (NSCUs) are rare and potentially life-threatening lesions of unknown etiology; the diagnosis is based on histologic findings showing nonspecific inflammatory changes. The condition's variable symptoms can include nonspecific abdominal discomfort, gastrointestinal bleeding, perforation, and peritonitis. Radiologic imaging can be helpful in locating the lesions, but colonoscopy facilitates early definitive diagnosis and aggressive treatment. The potential of NSCUs to recur is currently unknown, and morbidity rates remain high. Long-term colonoscopic follow-up may improve the prognosis.
References
-
1
Ona F V, Allende H D, Vivenzio R. et al .
Diagnosis and management of nonspecific colon ulcer.
Arch Surg.
1982;
117
888-894
-
2
Velitchkov N G, Losanoff J E, Kjossev K T. et al .
Perforated nonspecific ulcer of the sigmoid colon: four cases in one year.
Rozhl Chir.
1995;
74
147-149
-
3
Ando Y, Kikuchi K, Ichikawa N. et al .
A nonspecific colonic ulcer occurring after hepatectomy: report of a case.
Surg Today.
1997;
27
353-356
-
4 Thayer W R, Denucci T. Miscellaneous diseases of the large bowel and anal canal. In: Kirsner JB, Shorter RG (eds) Diseases of the colon, rectum and anal canal. Baltimore; Williams & Wilkins 1988: 570-573
-
5
Mills B, Zuckerman G, Sicard G.
Discrete colon ulcers as a cause of lower gastrointestinal bleeding and perforation in end-stage renal disease.
Surgery.
1981;
89
548-52
-
6
Stylianos S, Forde K A, Benvenisty A I, Hardy M A.
Lower gastrointestinal hemorrhage in renal transplant recipients.
Arch Surg.
1988;
123
739-744
-
7
Varney M, Schmidt P, Reckmann M.
Two nonspecific cecal ulcers in a 6-year-old child as a cause of intestinal hemorrhage (in German).
Z Kinderchir.
1987;
42
52-54
-
8
Janusz A J.
Cecal ulcers.
South Dakota J Med.
1984;
37
25-26
-
9
Kocdor M A, Aydin C, Astarcioglu H. et al .
Perforated solitary ulcer of the colon: report of a case.
Dis Colon Rectum.
1998;
41
1059-1061
-
10
Bayerdörffer E, Sommer G A, Ottenjann R.
Solitary colonic ulcers.
Gastrointest Endosc.
1986;
32
433-434
-
11
Finucci G, Bianchini M, Micheli P. et al .
Benign ulcers of the cecum (in Italian).
Minerva Chir.
1997;
52
1447-1450
-
12
Shah N C, Ostrov A H, Cavallero J B, Rodgers J B.
Benign ulcers of the colon.
Gastrointest Endosc.
1986;
32
102-104
-
13
Ruiz O choa, Potel L esquereux, Puente D ominguez.
Simple ulcers of colon and rectum (in Spanish).
Rev Esp Enferm Dig.
1968;
27
1467-1473
-
14
Tzamalukas G, Schneider G.
On simple ulcers of the large and small intestines, their genesis and therapy (in German).
Zentralbl Chir.
1965;
90
1710-1715
-
15
Bjarnason I, Macpherson A J.
Intestinal toxicity of non-steroidal anti-inflammatory drugs.
Pharmacol Ther.
1994;
62
145-157
-
16
Lee R G.
The colitis of Behçet's syndrome.
Am J Surg Pathol.
1986;
10
888-893
-
17
Rubio C A, Nydahl S.
“Nonspecific” erosions and ulcers of the colonic mucosa.
Dig Dis Sci.
1994;
39
821-826
-
18
Pfeifer M, Kogel H, Heymer B.
Cholesterol crystal embolization, a rare cause of postoperative ischemic colitis (in German).
Vasa.
1990;
19
54-58
-
19
Fisher J K.
Intramural diverticulosis simulating aphthous ulceration of the colon.
Mo Med.
1986;
83
687-689
-
20
Miller L S, Barbarevech C, Friedman L S.
Less frequent causes of lower gastrointestinal bleeding.
Gastroenterol Clin North Am.
1994;
23
21-52
-
21
Degawa H, Tomikawa S, Nagao T, Uchiga H.
A nonspecific colonic ulcer occurring after hepatectomy: report of a case.
Surg Today.
1997;
27
353-356
-
22
Chari S T, Keate R F.
Ileocolonic anastomotic ulcers: a case series and review of the literature.
Am J Gastroenterol.
2000;
95
1239-1243
-
23
Still J M, Scheirer R C, Law E J.
Cecal perforation due to colonic ulcer in a burn patient.
Burns.
1994;
20
85-86
-
24
Ferguson C M, Siegel R J.
A prospective evaluation of diversion colitis.
Am Surg.
1991;
57
46-49
-
25
Robinson M H, Wheatley T, Leach I H.
Nonsteroidal anti-inflammatory drug-induced colonic stricture: an unusual cause of large bowel obstruction and perforation.
Dig Dis Sci.
1995;
40
315-319
-
26
Bernardino M E, Lawson T L.
Discrete colonic ulcers associated with oral contraceptives.
Am J Dig Dis.
1976;
21
503-506
-
27
Arvanitakis C.
Recurrent colonic ulcers in celiac sprue, an unrecognized fatal complication: report of a case.
Dis Colon Rectum.
1977;
20
613-617
-
28
Lazarovitch I, Michowitz M, Lowenthal M, Solowiejczyk M.
Nonspecific ulcers of the cecum: report of two cases.
Dis Colon Rectum.
1974;
17
381-386
-
29
Mahoney T J, Bubrick M P, Hitchcock C R.
Nonspecific ulcers of the colon.
Dis Colon Rectum.
1978;
21
623-626
-
30
Khawaja F I, Vakil N.
Colonoscopy as an aid in the diagnosis of nonspecific ulcers of the colon.
Gastrointest Endosc.
1987;
33
43-45
-
31
Leborgne J, Bitar O, Lehur P A. et al .
(Post-stress acute hemorrhagic ulcers of the cecum: apropos of 3 cases (in French).
Chirurgie.
1992;
118
637-639
-
32
Butsch J L, Dockerty M B, McGill D B, Judd E S.
“Solitary” nonspecific ulcers of the colon.
Arch Surg.
1969;
98
171-174
-
33
Gardiner G A, Bird R.
Nonspecific ulcers of the colon resembling annular carcinoma.
Radiology.
1980;
137
331-334
-
34
Maniatis V, Chryssikopoulos H, Roussakis A. et al .
Perforation of the alimentary tract: evaluation with computed tomography.
Abdom Imaging.
2000;
25
373-379
-
35
Cho K, Baker S.
Extraluminal air: diagnosis and significance.
Radiol Clin North Am.
1994;
32
829-844
-
36
Sutherland D, Frech R S, Weil R. et al .
The bleeding cecal ulcer: pathogenesis, angiographic diagnosis, and nonoperative control.
Surgery.
1972;
71
290-294
-
37
Barbier P, Luder P, Triller J. et al .
Colonic hemorrhage from a solitary minute ulcer: report of three cases.
Gastroenterology.
1985;
88
1065-1068
-
38
Schläpfer H U, Nüesch H J, Kobler E. et al .
Nonspecific ulcer of the colon: a report on 12 endoscopically diagnosed cases (in German).
Schweiz Med Wochenschr.
1979;
109
609-610
-
39
Graham D J, Pritchard T J, Bloom A D.
Colonoscopy for intermittent rectal bleeding: impact on patient management.
J Surg Res.
1993;
54
136-139
-
40
Miller S M, Juhl J H.
Nonspecific ulcers of the colon.
Minn Med.
1967;
50
1327-1332
-
41
Bayerdörffer E, Sommer A, Weingart J, Ottenjann R.
Gastrointestinal bleeding in solitary colon ulcers.
Deutsch Med Wochenschr.
1987;
112
53-56
-
42
Quintans R odriguez, Hernandez G ranados, Serantes G omez. et al .
Massive rectal hemorrhage caused by nonspecific colonic ulcers (in Spanish).
Rev Esp Enferm Dig.
1993;
84
61-63
-
43
Sato H, Tatsumura T, Yamamoto K.
A perforated non-specific ulcer of the cecum as seen in a 2-year-old female.
Surg Today.
1992;
22
376-378
-
44
Finucci G, Bianchini M, Micheli P. et al .
Benign ulcers of the cecum (in Italian).
Minerva Chir.
1997;
52
1447-1450
J. W. Jones, M.D., Ph. D.
Dept. of Surgery · M580 Health Sciences Center · University of Missouri-Columbia School of Medicine
One Hospital Drive · Columbia, MO 65212 · USA
Fax: + 1-573-884-4585 ·
Email: JonesJW@health.missouri.edu
