Synlett 2003(8): 1170-1174
DOI: 10.1055/s-2003-39885
LETTER
© Georg Thieme Verlag Stuttgart ˙ New York

Synthesis of Optically Active Prostaglandin-J2 and 15-Deoxy-Δ12,14-prosta-glandin-J2

Jamie F. Bickleya, Vasudev Jadhava, Stanley M. Robertsa, M. Gabriella Santorob, Alexander Steinera, Peter W. Sutton*c
a Robert Robinson Laboratories, Department of Chemistry, University of Liverpool, Liverpool, L69 7ZD, UK
b Department of Biology, University of Rome-Tor Vergata, Via Della Ricerca Scientifica, 00133 Rome, Italy
c Stylacats Ltd., Department of Organic Chemistry, University of Barcelona, Marti i Franques 1-11, 08028 Barcelona, Spain
Fax: +34(93)3397878; e-Mail: pete.sutton@stylacats.com;
Further Information

Publication History

Received 17 March 2003
Publication Date:
11 June 2003 (online)

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Abstract

An efficient route to optically pure prostaglandin-J2 compounds has been discovered: ent-PGJ2 is shown to display anti-viral activity against Sendai virus with a similar potency to the natural enantiomer.