Planta Med 2003; 69(6): 555-556
DOI: 10.1055/s-2003-40636
Letter
© Georg Thieme Verlag Stuttgart · New York

Inhibition of Na+,K+-ATPase Activity by (-)-ent-Kaur-16-en-19-oic Acid and its Derivatives

Nattaya Ngamrojnavanich1 , Supaporn Sirimongkon1 , Sophon Roengsumran1 , Amorn Petsom1 , Hishashi Kamimura2
  • 1Research Centre for Bioorganic Chemistry, Department of Chemistry, Faculty of Science, Chulalongkorn University, Pathumwan, Bangkok, Thailand
  • 2Division of Drug, The Tokyo Metropolitan Research Laboratory of Public Health, Tokyo, Japan
Further Information

Publication History

Received: October 21, 2002

Accepted: February 15, 2003

Publication Date:
16 July 2003 (online)

Abstract

The diterpene, (-)-ent-kaur-16-en-19-oic acid, from Croton oblongifolius was identified as an Na+,K+-ATPase inhibitor. This compound exhibits an IC50 of 2.2 × 10-5 M against crude enzyme Na+,K+-ATPase from rat brain. The semi-synthetic derivatives, (-)-methyl kaur-16-en-19-oate, (-)-kaur-16-en-19-ol, (-)-16β,17-epoxykauran-19-oic acid and (-)-17-hydroxykaur-15-en-19-oic acid were also tested and their IC50 were 5.5 × 10-4, 5.0 × 10-4, 4.8 × 10-4 and 6.0 × 10-4 M, respectively.

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Dr. Nattaya Ngamrojnavanich

Research Centre for Bioorganic Chemistry

Department of Chemistry

Faculty of Science

Chulalongkorn University

Bangkok 10330

Thailand

Fax: +66-2-253-0321

Email: nnattaya@chula.ac.th