Brønsted Acid-Mediated Synthesis of α-Amino Phosphonates under Solvent-Free Conditions

Abstract

Three-component reactions of aldehydes, amine, and diethyl phosphite by means of CF₃COOH under the solvent-free conditions afforded α-amino phosphonates in excellent yields.

Key words

phosphonates - imines - nucleophilic additions - amine - diethyl phosphite

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21

For the synthesis of α-amino phosphonate under solvent-free conditions, see; refs. [15-17]

22

Acetophenone did not react under the same reaction conditions.