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Neuropediatrics 2003; 34(3): 146-148
DOI: 10.1055/s-2003-41271
Short Communication

Georg Thieme Verlag Stuttgart · New York

Familial Bilateral Medial Parietooccipital Band Heterotopia not Related to DCX or LIS1 Gene Defects

N. Deconinck 1 , T. Duprez 2 , V. des Portes 3 , C. Beldjord 4 , S. Ghariani 1 , C. J. M. Sindic 5 , G. Sébire 1
  • 1Service de Neurologie Pédiatrique, Cliniques Universitaires Saint-Luc, Université Catholique de Louvain, Brussels, Belgium
  • 2Service de Radiologie, Cliniques Universitaires Saint-Luc, Université Catholique de Louvain, Brussels, Belgium
  • 3Service de Neuropédiatrie, Hôpital Saint Vincent de Paul, Paris France
  • 4Laboratoire de Biochimie et de Biologie Moléculaire, Hôpital Cochin, Paris, France
  • 5Service de Neurologie, Cliniques Universitaires Saint-Luc, Université Catholique de Louvain, Brussels, Belgium
Further Information

Publication History

Received: March 15, 2002

Accepted after Revision: February 17, 2003

Publication Date:
11 August 2003 (online)

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Abstract

A father and his daughter displayed strictly similar focal brain dysplasia at MR examination, characterized by regional medial posterior laminar sub-cortical grey matter heterotopia. To our knowledge, no family presenting such anomalies has yet been described. LIS1 and DCX gene defects were excluded. Collecting patients with such inherited dysplasia should improve our knowledge of the genetic basis of cortical malformations.

Key words

Brain Malformation - Heterotopia - Mental Deficiency - Epilepsy

References

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G. Sébire

Service de Neurologie Pédiatrique, CHU Fleurimont, Université de Sherbrooke

3001 12ème Av. Nord

J1H 5N4, Sherbrooke

Canada

Email: gsebire@compuserve.com