Effect of the Michael Acceptor in the Asymmetric Intramolecular Stetter Reaction

Abstract

The effect of different Michael acceptors was evaluated in the catalytic asymmetric intramolecular Stetter reaction. Utilizing a readily prepared chiral triazolium salt as a nucleophilic carbene precursor, the reactivity and selectivity of substrates containing different electron-deficient double bonds was shown to vary significantly under identical reaction conditions.

nucleophilic carbenes - catalytic asymmetric Stetter - Michael acceptors - umpolung chemistry

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