Bicarbonate Salts as Cost-Effective Bases for the Synthesis of Ketenes and Their Synthetic Equivalents Applied to the Asymmetric Synthesis of β-Lactams

Meha H. Shah; Stefan France; Thomas Lectka

doi:10.1055/s-2003-41497

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Bicarbonate Salts as Cost-Effective Bases for the Synthesis of Ketenes and Their Synthetic Equivalents Applied to the Asymmetric Synthesis of β-Lactams

Meha H. Shah, Stefan France, Thomas Lectka*
Department of Chemistry, Johns Hopkins University, 3400 N. Charles St., Baltimore, MD 21218, USA
Fax: +1(410)5168420; e-Mail: lectka@jhu.edu;

Abstract

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Abstract

We report the use of bicarbonate salts as viable alternatives to more expensive bases for the in situ generation of ketenes and their synthetic equivalents. We have successfully applied this to the catalytic, asymmetric synthesis of β-lactams.

Key words

β-lactam - bicarbonate salts - asymmetric catalysis - cinchona alkaloids

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References

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