Zusammenfassung
Die Mehrzahl aller Parkinson-Patienten entwickelt im Laufe der medikamentösen Therapie ihrer Erkrankung motorische Probleme wie zunehmend schlechteres Ansprechen auf dopaminerge Medikation, Fluktuationen und Dyskinesien. Zudem treten häufig nichtmotorische Probleme wie Demenz, Angst, Depression, autonome Störungen und therapieresistente Phänomene wie Gangstörungen, Sprechstörungen, Fallneigung und Freezing hinzu. Die Behandlung dieser Komplikationen stellt eine Herausforderung sowohl für den Arzt als auch für den Patienten und seine Angehörigen dar. In diesem Artikel werden medikamentöse Therapiestrategien zur Behandlung von Komplikationen im Spätstadium des M. Parkinson zusammengefasst.
Abstract
The majority of patients with Parkinson's disease experiences motor complications during long-term treatment of their disease including a decreasing response to dopaminergic stimulation, motor fluctuations, and dyskinesias. Many patients also develop non-motor problems such as dementia, depression, autonomic dysfunction and therapy-resistent phenomena like gait disorders, speech disorders, postural instability, falls, and freezing. This article summarizes current treatment strategies in the drug management of motor complications in advanced Parkinson's disease.
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Prof. Dr. Markus Naumann
Neurologische Klinik der Bayerischen Julius-Maximilians-Universität Würzburg
Josef-Schneider-Straße 11
97080 Würzburg
Email: naumann@mail.uni-wuerzburg.de
