The synthesis and characterization of a series of 4-nitrosophenyl-1,4-dihydropyridines
derived from the respective nitro compounds of pharmacological interest is described.
The complete synthetic pathway is based on the classical Hantzsch 1,4-dihydropyridine
synthesis to obtain the nitrophenyl 1,4-dihydropyridines in a first step, followed
by chemical reduction of the nitro compound to the corresponding hydroxylamine and
further oxidation to the nitroso derivative. The synthesis and characterization of
the compounds is described.
Hantzsch synthesis - pyridines - reductions - drugs - nitroso compounds
