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DOI: 10.1055/s-2003-43215
© Georg Thieme Verlag Stuttgart · New York
Cytotoxic Alkaloids from Boehmeria siamensis
Publication History
Received: December 27, 2002
Accepted: March 29, 2003
Publication Date:
04 November 2003 (online)
![](https://www.thieme-connect.de/media/plantamedica/200309/lookinside/thumbnails/10.1055-s-2003-43215-1.jpg)
Abstract
Two new phenanthroquinolizidine alkaloids, boehmeriasins A and B, were isolated from the aqueous ethanolic extract of Boehmeria siamensis Craib (Urticaceae) by bioassay-guided fractionation. Their structures were elucidated on the basis of spectral evidence. Boehmeriasin A possesses cytotoxic activity against 12 cell lines from 6 panels of cancer including lung cancer, colon cancer, breast cancer, prostate cancer, kidney cancer and leukemia with GI50 between 0.2 and 100 ng/mL, whereas boehmeriasin B showed lower activity.
Key words
Boehmeria siamensis - Urticaceae - boehmeriasin A - boehmeriasin B - cytotoxic activity
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Prof. Dr. Guolin Zhang
Chengdu Institute of Biology
The Chinese Academy of Sciences
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