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Synlett 2004(2): 0235-0238
DOI: 10.1055/s-2003-43374
DOI: 10.1055/s-2003-43374
LETTER
© Georg Thieme Verlag Stuttgart · New York
A Novel Cu-catalysed Three-component One-pot Synthesis of Dihydropyrimidin-2(1H)-ones Using Microwaves under Solvent-free Conditions
Weitere Informationen
Received
4 September 2003
Publikationsdatum:
18. Dezember 2003 (online)
Publikationsverlauf
Publikationsdatum:
18. Dezember 2003 (online)
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Abstract
Cupric chloride dihydrate catalyzes the three-component Biginelli condensation between an aldehyde, a β-ketoester and urea or thiourea under microwave irradiation in the absence of solvent to yield various substituted 3,4-dihydropyrimidin-2(1H)-ones. The reaction is also effective when performed at room temperature in acetonitrile or at 100 °C in a solvent free approach, without any side reactions as observed by Biginelli and others.
Key words
Biginelli condensation - cupric chloride - cupric sulphate - dihydropyrimidinones, - three-component reactions
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