Tumor Microenvironment and Hemorheological Abnormalities

Gianfranco Baronzio; Isabel Freitas; Hau C. Kwaan

doi:10.1055/s-2003-44557

Seminars in Thrombosis and Hemostasis, Table of Contents

Semin Thromb Hemost 2003; 29(5): 489-498
DOI: 10.1055/s-2003-44557

Tumor Microenvironment and Hemorheological Abnormalities

Gianfranco Baronzio¹ , Isabel Freitas² , Hau C. Kwaan³

¹Physician, Family Medicine Area, ASl 1 Legnano, Milano, Italy
²Professor of Cell Biology, Department of Animal Biology and CNR Institute of Molecular Genetics, University of Pavia, Pavia, Italy
³Professor, Division of Hematology/Oncology, Northwestern University Feinberg School of Medicine, Chicago, Illinois

Abstract

ABSTRACT

This article reviews the various mechanisms in a malignant tumor that lead to hypoxia, production of tumor interstitial fluid, and rheological changes in its microenvironment. In addition, the associated procoagulant effects are described. The latter phenomenon is the result of complex and dynamic interplay among tumor cells, endothelial cells, circulating blood cells, and angiogenic, clotting, and hemorheological factors. The implications of these abnormalities on therapeutic approach are discussed.

KEYWORDS

Hypoxia - tumor interstitial fluid - VEGF - thrombosis - hemorheology

Full Text

References

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