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Semin Thromb Hemost 2003; 29(5): 489-498
DOI: 10.1055/s-2003-44557
DOI: 10.1055/s-2003-44557
Tumor Microenvironment and Hemorheological Abnormalities
Further Information
Publication History
Publication Date:
21 November 2003 (online)
ABSTRACT
This article reviews the various mechanisms in a malignant tumor that lead to hypoxia, production of tumor interstitial fluid, and rheological changes in its microenvironment. In addition, the associated procoagulant effects are described. The latter phenomenon is the result of complex and dynamic interplay among tumor cells, endothelial cells, circulating blood cells, and angiogenic, clotting, and hemorheological factors. The implications of these abnormalities on therapeutic approach are discussed.
KEYWORDS
Hypoxia - tumor interstitial fluid - VEGF - thrombosis - hemorheology
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