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DOI: 10.1055/s-2003-45158
2-(4′-Aminobenzenamine)-pyrimidine, A New α-Antagonist from Autonoë madeirensis
This research was carried out with financial support from Fundação para a Ciência e Tecnologia (POCTI/FEDER)Publikationsverlauf
Received: June 2, 2003
Accepted: August 10, 2003
Publikationsdatum:
09. Januar 2004 (online)
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Abstract
A new natural pyrimidine derivative, 2-(4′-aminobenzenamine)-pyrimidine (1), was isolated from the bulbs of Autonoë madeirensis, a Hyacinthaceae of the Madeira Archipelago (Portugal) and the structure determined on the basis of spectroscopic data. As some pyrimidine compounds are important α1-adrenergic antagonists, we investigated the effect of 1 on rat vas deferens contractility induced by the α1-agonist phenylephrine. In concentrations virtually devoid of effect on the rat vas deferens contractility, 1 shifted to the right the concentration-response curves of phenylephrine without changing the maximal effect. These results provide evidence that 1 acts as an α1-adrenoceptor antagonist and suggest a competitive mechanism of action.
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Alexandra Paulo
Faculty of Pharmacy
University of Lisbon
Av. Prof. Gama Pinto
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Portugal
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