Current Issues in the Diagnosis and Management of Dementia

Richard J. Caselli

doi:10.1055/s-2003-814743

Seminars in Neurology, Table of Contents

Semin Neurol 2003; 23(3): 231-240
DOI: 10.1055/s-2003-814743

Current Issues in the Diagnosis and Management of Dementia

Richard J. Caselli

Department of Neurology, Mayo Clinic Scottsdale, Scottsdale, Arizona

Abstract

ABSTRACT

Aging, memory loss, Alzheimer's disease, and other forms of dementia assume increasing importance to patients, physicians, and society as our population becomes older. Mild cognitive impairment, topography and semiology of dementia syndromes, reversible forms of dementia, dementia therapy, driving, genetic testing of patients and family members, and caregiver risk are reviewed.

KEYWORDS

Alzheimer's disease - dementia - memory loss - dementia with Lewy bodies - memory - mild cognitive impairment - reversible dementia

Full Text

References

REFERENCES

1 Morris J C, Storandt M, Miller J P. et al . Mild cognitive impairment represents early-stage Alzheimer disease. Arch Neurol . 2001; 58 397-405
2 Petersen R C, Doody R, Kurz A. et al . Current concepts in mild cognitive impairment. Arch Neurol . 2001; 58 1985-1992
3 Dubinsky R M, Stein A C, Lyons K. Risk of driving and Alzheimer's disease (an evidence based review): report of the Quality Standards Subcommittee of the American Academy of Neurology. Neurology . 2000; 54 2205-2211
4 Caselli R J, Reiman E M, Stelmach G E. et al . Progressive apraxia in clinically discordant monozygotic twins. Arch Neurol . 1995; 52 1004-1010
5 Caselli R J, Stelmach G E, Caviness J N. et al . A kinematic study of progressive apraxia with and without dementia. Mov Disord . 1999; 14 276-287
6 Caselli R J, Jack Jr R C, Petersen R C. et al . Asymmetric cortical degenerative syndromes: Clinical and radiologic correlations. Neurology . 1992; 42 1462-1468
7 Caselli R J, Jack Jr R C. Asymmetrical cortical degeneration syndromes: a proposed clinical classification. Arch Neurol . 1992; 49 770-780
8 Caselli R J. Asymmetric cortical degeneration: syndromes and diseases. Neurologist . 1995; 1 1-20
9 Caselli R J. Asymmetric cortical degeneration syndromes. Curr Opin Neurol . 1996; 9 276-280
10 Boeve B F, Maraganore D M, Parisi J E. et al . Pathologic heterogeneity in clinically diagnosed corticobasal degeneration. Neurology . 1999; 53 795-800
11 Caselli R J. Corticobasal degeneration: its relationship to other asymmetric cortical degenerative syndromes. Adv Neurol . 2000; 82 35-51
12 Caselli R J. Visual syndromes as the presenting feature of degenerative brain disease. Semin Neurol . 2000; 20 139-144
13 Caselli R J. Topography, histology, and seminology in dementia (letter). Arch Neurol . 2000; 57 899
14 Caselli R J, Beach T G, Sue L I, Connor D J, Sabbagh M N. Progressive aphasia with Lewy bodies. Dement Geriatr Cogn Disord . 2002; 14 55-58
15 Caselli R J, Boeve B F, Scheithauer B W. et al . Nonvasculitic autoimmune inflammatory meningoencephalitis (NAIM): a reversible form of encephalopathy. Neurology . 1999; 53 1579-1581
16 McKeith I G, Galasko D, Kosaka K. et al . Consensus guidelines for the clinical and pathologic diagnosis of dementia with Lewy bodies (DLB): report of the consortium on DLB international workshop. Neurology . 1996; 47 1113-1124
17 Caselli R J, Couce M E, Osborne D. et al . From slowly progressive amnesic syndrome to rapidly progressive Alzheimer disease. Alzheimer Dis Assoc Disord . 1998; 12 251-253
18 Boeve B F, Silber M H, Ferman T J, Lucas J A, Parisi J E. Association of REM sleep behavior disorder and neurodegenerative disease may reflect an underlying synucleinopathy. Mov Disord . 2001; 16 622-630
19 Shumaker S A, Legault C, Rapp S R. et al . Estrogen plus progestin and the incidence of dementia and mild cognitive impairment in postmenopausal women. The women's health initiative memory study: a randomized controlled trial. JAMA . 2003; 289 2651-2662
20 Aisen P S, Schafer K A, Grundman M. et al . Effects of rofecoxib or naproxen vs placebo on Alzheimer disease progression. A randomized controlled trial. JAMA . 2003; 289 2819-1826
21 Morris J C. The Clinical Dementia Rating (CDR): current version and scoring rules. Neurology . 1993; 43 2412-2414
22 Hunt L, Morris J C, Edwards D, Wilson B S. Driving performance in persons with mild senile dementia. J Am Geriatr Soc . 1993; 41 747-752
23 Flitten L J, Perryman K M, Wilkinson C J. et al . Alzheimer and vascular dementias and driving. JAMA . 1995; 273 1360-1365
24 Hunt L A, Murphy C F, Carr D, Duchek J M, Buckles V, Morris J C. Reliability of the Washington University Road Test: a performance based assessment for drivers with dementia of the Alzheimer type. Arch Neurol . 1997; 54 707-712
25 Fox G K, Bowden S C, Bashford G M, Smith D S. Alzheimer disease and driving: prediction and assessment of driving performance. J Am Geriatr Soc . 1997; 45 949-953
26 Duchek J M, Hunt L, Ball K, Buckles V, Morris J C. Attention and driving performance in Alzheimer's disease. J Gerontol . 1998; 53 130-141
27 Rebok G W, Keyl P M, Bylsma F W, Blaustein M J, Tune L. The effects of Alzheimer's disease on driving-related abilities. Alzheimer Dis Assoc Disord . 1994; 8 228-240
28 Rizzo M, Reinach S, McGehee D, Dawson J. Simulated car crashes and crash predictors in Alzheimer disease. Arch Neurol . 1997; 54 545-551
29 Cox D J, McQuillian W C, Thorndike F P, Kovatchev B P, Hanna G. Evaluating driving performance of outpatients with Alzheimer's disease. J Am Board Fam Pract . 1998; 11 264-271
30 Drachman D A, Swearer J M. Driving and Alzheimer's disease: the risk of crashes. Neurology . 1993; 43 2448-2456
31 Logsdon R G, Teri L, Larson E B. Driving and Alzheimer's disease. J Gen Intern Med . 1992; 7 583-588
32 Sherrington R, Rogaev E L, Liang Y. et al . Cloning of a gene bearing missense mutation in early-onset familial Alzheimer's disease. Nature . 1995; 375 754-760
33 Wisniewski K E, Wiesniewski H M, Wen G Y. Occurrence of neuropathological changes and dementia of Alzheimer's disease in Down's syndrome. Ann Neurol . 1985; 17 278-282
34 Levy-Lahad E, Wasco W, Pookaj P. et al . Candidate gene for the chromosome 1 familial Alzheimer's disease locus. Science . 1995; 269 973-977
35 Hardy J, Higgins G. Alzheimer's disease-the amyloid cascade hypothesis. Science . 1992; 256 184-185
36 Corder E H, Saunders A M, Strittmatter W J. et al . Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families. Science . 1993; 261 921-923
37 Saunders A M, Strittmatter W J, Schmechel D. et al . Association of apolipoprotein E e4 allele with late onset familial and sporadic Alzheimer's disease. Neurology . 1993; 43 1467-1472
38 Ertekin-Taner N, Graff-Radford N R, Younkin L H. et al . Linkage of plasma Abeta42 to a quantitative locus on chromosome 10 in late-onset Alzheimer's disease pedigrees. Science . 2000; 290 2303-2304
39 Wu W S, Holmans P, Wavrant-DeVrieze F. et al . Genetic studies on chromosome 12 in late-onset Alzheimer disease. JAMA . 1998; 280 619-622
40 Caselli R J, Reiman E M, Hentz J G, Osborne D, Alexander G E, Boeve B F. A distinctive interaction between memory and chronic daytime somnolence in asymptomatic APOE e4 homozygotes. Sleep . 2002; 25 447-453
41 Caselli R J, Reiman E M, Hentz J G, Osborne D, Alexander G E. A distinctive interaction between chronic anxiety and problem solving in APOE e4 homozygotes (in press). J Neuropsychiatry Clin Neurosci.
42 Caselli R J, Graff-Radford N R, Reiman E M. et al . Preclinical memory decline in cognitively normal apolipoprotein E-e4 homozygotes. Neurology . 1999; 53 201-207
43 Caselli R J, Osborne D, Reiman E M. et al . Preclinical cognitive decline in late middle-aged asymptomatic apolipoprotein E-e4/4 homozygotes: a replication study. J Neurol Sci . 2001; 189 93-98
44 Baxter L C, Caselli R J, Johnson S C, Reiman E M, Osborne D. Apolipoprotein E varepsilon 4 affects new learning in cognitively normal individuals at risk for Alzheimer's disease. Neurobiol Aging . 2003; 24 947-952
45 Reiman E M, Caselli R J, Yun L S. et al . Preclinical evidence of a genetic risk factor for Alzheimer's disease in apolipoprotein E type 4 homozygotes using positron emission tomography (with editorial). N Engl J Med . 1996; 334 752-758
46 Reiman E M, Caselli R J, Chen K, Alexander G E, Bandy D, Frost J. Declining brain activity in cognitively normal apolipoprotein E e4 heterozygotes: a foundation for testing Alzheimer's dementia prevention therapies. Proc Natl Acad Sci U S A . 2001; 98 3334-3339
47 Reiman E M, Caselli R J, Alexander G E, Chen K. Tracking the decline in cerebral glucose metabolism in persons and laboratory animals at genetic risk for Alzheimer's disease. Clin Neurosci Res . 2001; 28 194-206
48 Reiman E M, Chen K, Alexander G E. et al . Functional brain abnormalities in young adults at genetic risk for late-onset Alzheimer's dementia (in press). Proc Natl Acad Sci.
49 Relkin N R, Kwon Y J, Tsai J, Gandy S. The National Institute on Aging/Alzheimer's Association recommendations on the application of apolipoprotein E genotyping to Alzheimer's disease. Ann N Y Acad Sci . 1996; 802 149-176
50 Eastley R, Wilcock G K. Prevalence and correlates of aggressive behaviours occurring in patients with Alzheimer's disease. Int J Geriatr Psychiatry . 1997; 12 484-487
51 Mendez M F, Perryman K M, Miller B L, Cummings J L. Behavioral differences between frontotemporal dementia and Alzheimer's disease: a comparison on the BEHAVE-AD rating scale. Int Psychogeriatr . 1998; 10 155-162