Subscribe to RSS
DOI: 10.1055/s-2004-813281
© Georg Thieme Verlag KG Stuttgart · New York
Biliary Infarction Mimicking Liver Metastasis
Vortäuschung von Lebermetastasen durch GalleninfarktePublication History
received: 2.12.2003
accepted: 6.3.2004
Publication Date:
09 August 2004 (online)
Zusammenfassung
Bei einem 38-jährigen alkoholkranken Patienten mit zahlreichen Schüben einer chronisch rezidivierenden Pankreatitis, welche durch eine Pankreaskopf-Pseudozyste kompliziert war, bestand eine lang anhaltende distale biliäre Obstruktion. Bei Aufnahme litt er seit 10 Tagen unter Erbrechen, Abdominalschmerzen und Diarrhö. Sonographisch wurden zahlreiche, umschriebene, echoarme Raumforderungen in beiden Leberlappen dargestellt. Die Computertomographie zeigte nach Lage und Größe entsprechende hypodense Leberherde. Da differenzialdiagnostisch Abszesse bzw. Metastasen vermutet wurden, wurden die Leberraumforderungen sonographiegesteuert mit der Feinnadel punktiert. Die histologische Untersuchung der Leberbiopsien ergab Galleninfarkte und proliferierte Gallengänge. Hinweise für Malignität oder Infektion fanden sich nicht. Die bakteriologische Untersuchung der Leberbiopsien war kulturell negativ.
Abstract
A 38-year-old man with a history of chronic alcohol abuse had suffered from numerous acute episodes of chronic pancreatitis in the last 7 years. Those episodes were complicated by the formation of a pseudocyst in the pancreatic head. He presented himself with vomiting and abdominal pain as well as diarrhoea for 10 days. In the ultrasound examination of the liver numerous circumscribed hypoechoic formations in both lobes of the liver were found. A subsequent computerised tomography scan confirmed multiple hypodense liver lesions. Because of suspected metastasis or abscesses in the liver, sonographically guided fine needle biopsies of these liver structures were carried out. The histological examination of the liver specimens showed bile infarcts and proliferated bile ducts; there were no signs of a malignant or infectious process. The bacteriological cultures of the biopsy specimens were negative.
Schlüsselwörter
Biliäre Obstruktion - Pankreatitis - intrahepatische Gallenwegserkrankung - Ultraschall - Computertomographie
Key words
Bile duct obstruction - pancreatitis - intrahepatic biliary tract diseases - ultrasound - computerised tomography
Referencee
- 1 Afroudakis A, Kaplowitz N. Liver histopathology in chronic common bile duct stenosis due to chronic alcoholic pancreatitis. Hepatology. 1981; 1 65-72
- 2 Bisceglie A M, Paterson A C, Segal I. The liver in biliary obstruction due to chronic pancreatitis. Liver. 1985; 5 189-195
- 3 Scheuer P, Lefkowitch J H. Biliray disease; furthermore see glossary. In: Scheuer P, Lefkowitch JH (eds). Liver biopsy interpretation. Fifth edition. London/Philadelphia/Toronto/Sydney/Tokoy; W. B. Saunders company 1994: 38 - 61, 303 - 304
- 4 Lygidakis N J. Histological changes and intrahepatic biliary abnormalities in extrahepatic biliary tract obstruction. Surg Gynecol Obstet. 1982; 153 532-536
- 5 Weinbren K, Hadjis N S, Blumgart L H. Structural aspects of the liver with biliary disease and portal hypertension. J Clin Pathol. 1985; 38 1013-1020
- 6 Lygidakis N J, Carlei F. Structural and functional biliary tree changes secondary to extrahepatic biliary obstruction. Endoscopy. 1989; 21 321-323
- 7 De Vos F, Desmet W J. Morphological changes of the junctional complex of hepatocytes in rat liver after bile duct ligation. Br J Exp Pathol. 1978; 59 220-224
- 8 Slott P A, Liu M H, Tavoloni N. Origin, pattern, and mechanism of bile duct proliferation following biliary obstruction in the rat. Gastroenterology. 1990; 99 466-477
- 9 Christoffersen P, Poulsen H. Histological changes in human liver biopsies following extrahepatic biliary obstruction. Acta Pathol Microbiol Scand. 1970; 212 (Suppl.) 150-157
- 10 Gibson W R, Robertson H E. So-called biliary cirrhosis. Archives of Pathology. 1939; 28 37-48
- 11 Foulk W T, Baggenstoss A H. Obstructive or secondary biliary cirrhosis. In: Schiff L (ed). Diseases of the liver. 4th ed. Philadelphia; J. B. Lippincott 1975: 959-967
- 12 Lygidakis N J. Abnormal drainage of the biliary tree after relief of long-standing extrahepatic biliary obstruction. Am J Surg. 1983; 146 318-321
Prof. Dr. Dr. Horst Weiler
Med. Klinik I
Posilipostraße 4
71640 Ludwigsburg
Phone: ++ 49/71 41/99 64 78