Epidemiology and Biology of Insulin-like Growth Factor Binding Protein-3 (IGFBP-3) as an Anti-cancer Molecule

O. Ali; P. Cohen; K.-W. Lee

doi:10.1055/s-2004-814146

Hormone and Metabolic Research, Table of Contents

Horm Metab Res 2003; 35(11/12): 726-733
DOI: 10.1055/s-2004-814146

Review

Epidemiology and Biology of Insulin-like Growth Factor Binding Protein-3 (IGFBP-3) as an Anti-cancer Molecule

O. Ali¹ , P. Cohen¹ , K.-W. Lee¹

¹Mattel Children’s Hospital at UCLA

Abstract

The Insulin-like Growth Factor (IGF) signaling system plays a central role in cellular growth, differentiation and proliferation. IGFBP-3 is the most abundant IGF binding protein in human serum and has been shown to be a growth inhibitory, apoptosis-inducing molecule, capable of acting via IGF-dependent and IGF-independent mechanisms. Over the last decade, several clinical studies have proposed that individuals with IGFBP-3 levels in the upper range of normal may have a decreased risk for certain common cancers. This includes evidence of a protective effect against breast cancer, prostate cancer, colorectal cancer, and lung cancer. In addition, a series of in vitro studies and animal experiments point towards an important role for IGFBP-3 in the regulation of cell growth and apoptosis. In this brief review, we discuss the biological role of IGFBP-3 and summarize the epidemiological and experimental evidence suggesting a role for IGFBP-3 as an anti-cancer molecule.

Key words

IGFBP-3 - IGF - Cancer - Growth factor - Binding Proteins

Full Text

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P. Cohen, M. D.

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