DOI: 10.1055/s-00000025

Hormone and Metabolic Research

Issue 11/12 · Volume 35 · November/December 2003 DOI: 10.1055/s-002-3023

Editorial

649
LeRoith, D.: Emerging Concepts in the Role of IGFs and Cancer

Original

651
Lee, A. V.; Taylor, S. T.; Greenall, J.; Mills, J. D.; Tonge, D. W.; Zhang, P.; George, J.; Fiorotto, M. L.; Hadsell, D. L.: Rapid Induction of IGF-IR Signaling in Normal and Tumor Tissue Following Intravenous Injection of IGF-I in Mice
656
Geenen, V.: The Thymic Insulin-like Growth Factor Axis: Involvement in Physiology and Disease
667
Foulstone, E. J.; Savage, P. B.; Crown, A. L.; Holly, J. M. P.; Stewart, C. E. H.: Adaptations of the IGF System during Malignancy: Human Skeletal Muscle versus the Systemic Environment
675
Strammiello , R.; Benini , S.; Manara , M. C.; Perdichizzi , S.; Serra , M.; Spisni , E.; Picci , P.; Scotlandi , K.: Impact of IGF-I/IGF-IR Circuit on the Angiogenetic Properties of Ewing’s Sarcoma Cells
734
Tu, X.; Wu, A.; Maiorana, A.; Baserga, R.: Subcellular Localization of IRS-1 in Cell Proliferation and Differentiation
751
Wu, J.; Haugk, K.; Plymate, S. R.: Activation of Pro-apoptotic p38-MAPK Pathway in the Prostate Cancer Cell Line M12 Expressing a Truncated IGF-IR
758
Abramovitch, S.; Werner, H.: Functional and Physical Interactions between BRCA1 and p53 in Transcriptional Regulation of the IGF-IR Gene
763
Butts, B. D.; Linseman, D. A.; Le, S. S.; Laessig, T. A.; Heidenreich, K. A.: Insulin-like Growth Factor-I Suppresses Degradation of the Pro-survival Transcription Factor Myocyte Enhancer Factor 2D (MEF2D) During Neuronal Apoptosis
786
Raile, K.; Hille, R.; Laue, S.; Schulz, A.; Pfeifer, G.; Horn, F.; Kiess, W.: Insulin-like Growth Factor I (IGF-I) Stimulates Proliferation but also Increases Caspase-3 Activity, Annexin-V Binding, and DNA-fragmentation in Human MG63 Osteosarcoma Cells: Co-activation of Pro- and Anti-apoptotic Pathways by IGF-I
794
Koda, M.; Sulkowski, S.; Garofalo, C.; Kanczuga-Koda, L.; Sulkowska, M.; Surmacz, E.: Expression of the Insulin-like Growth Factor-I Receptor in Primary Breast Cancer and Lymph Node Metastases: Correlations with Estrogen Receptors α and β
816
Hoeflich, A.; Fettscher, O.; Preta, G.; Lahm, H.; Kolb, H. J.; Wolf, E.; Weber, M. M.: Increased Activity of Catalase in Tumor Cells Overexpressing IGFBP-2
822
Gallicchio, M. A.; van Sinderen, M.; Bach, L. A.: Insulin-like Growth Factor Binding Protein-6 and CCI-779, an Ester Analogue of Rapamycin, Additively Inhibit Rhabdomyosarcoma Growth
836
Ye, J.-J.; Liang, S.-J.; Guo, N.; Li, S.-L.; Wu, A. M.; Giannini, S.; Sachdev, D.; Yee, D.; Brünner, N.; Ikle, D.; Fujita-Yamaguchi, Y.: Combined Effects of Tamoxifen and a Chimeric Humanized Single Chain Antibody against the Type I IGF Receptor on Breast Tumor Growth In vivo
850
Jackson-Booth, P.-G.; Terry, C.; Lackey, B.; Lopaczynska, M.; Nissley, P.: Inhibition of the Biologic Response to Insulin-like Growth Factor I in MCF-7 Breast Cancer Cells by a New Monoclonal Antibody to the Insulin-like Growth Factor-I Receptor. The Importance of Receptor Down-regulation

Review

664
Zumkeller, W.: The Role of the GH/IGF System in Pituitary Tumorigenesis
685
Scharf , J.-G.; Braulke , T.: The Role of the IGF Axis in Hepatocarcinogenesis
694
Giovannucci, E.: Nutrition, Insulin, Insulin-like Growth Factors and Cancer
705
Sell, Ch.: Caloric Restriction and Insulin-like Growth Factors in Aging and Cancer
712
Renehan, A. G.; O’Connell, J.; O’Halloran, D.; Shanahan, F.; Potten, C. S.; O’Dwyer, S. T.; Shalet, S. M.: Acromegaly and Colorectal Cancer: A Comprehensive Review of Epidemiology, Biological Mechanisms, and Clinical Implications
726
Ali, O.; Cohen, P.; Lee, K.-W.: Epidemiology and Biology of Insulin-like Growth Factor Binding Protein-3 (IGFBP-3) as an Anti-cancer Molecule
740
Dupont, J.; Pierre, A.; Froment, P.; Moreau, C.: The Insulin-like Growth Factor Axis in Cell Cycle Progression
771
O'Connor, R.: Regulation of IGF-I Receptor Signaling in Tumor Cells
778
Denley, A.; Wallace, J. C.; Cosgrove, L. J.; Forbes, B. E.: The Insulin Receptor Isoform Exon 11- (IR-A) in Cancer and Other Diseases: A Review
802
Zhang, D.; Samani, A. A.; Brodt, P.: The Role of the IGF-I Receptor in the Regulation of Matrix Metalloproteinases, Tumor Invasion and Metastasis
809
Flint, D. J.; Beattie, J.; Allan, G. J.: Modulation of the Actions of IGFs by IGFBP-5 in the Mammary Gland
828
Perks, C.; Holly, J.: Actions of IGFBP on Epithelial Cancer Cells: Potential for New Therapeutic Targets
843
Salisbury, A. J.; Macaulay, V. M.: Development of Molecular Agents for IGF Receptor Targeting
857
Gray, S. G.; Stenfeldt Mathiasen, I.; De Meyts, P.: The Insulin-like Growth Factors and Insulin-signalling Systems: An Appealing Target for Breast Cancer Therapy?