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Horm Metab Res 2003; 35(11/12): 705-711
DOI: 10.1055/s-2004-814156
Review
© Georg Thieme Verlag Stuttgart · New York

Caloric Restriction and Insulin-like Growth Factors in Aging and Cancer

Ch.  Sell1
  • 1Lankenau Institute for Medical Research
Further Information

Publication History

Received 2 September 2003

Accepted after Revision 15 October 2003

Publication Date:
07 January 2004 (online)

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Abstract

This review examines the influence of a reduction in caloric intake on cancer and longevity. Data indicating that rodents subjected to caloric restriction display lower tumor incidence, reduced susceptibility to carcinogens and extended lifespan is analyzed. The potential role of the growth hormone/insulin-like growth factor type 1 (IGF-I) axis in this effect is discussed as is the evidence that a reduction in growth hormone and/or IGF-I leads to a reduction in spontaneous tumors and susceptibility to carcinogens.

Key words

Cancer - Aging - Insulin-like growth factor - Caloric restriction

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Ch. Sell

Lankenau Institute for Medical Research

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Email: sellc@mlhs.org