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Horm Metab Res 2003; 35(11/12): 705-711
DOI: 10.1055/s-2004-814156
DOI: 10.1055/s-2004-814156
Review
© Georg Thieme Verlag Stuttgart · New York
Caloric Restriction and Insulin-like Growth Factors in Aging and Cancer
Ch. Sell1Further Information
Publication History
Received 2 September 2003
Accepted after Revision 15 October 2003
Publication Date:
07 January 2004 (online)
Abstract
This review examines the influence of a reduction in caloric intake on cancer and longevity. Data indicating that rodents subjected to caloric restriction display lower tumor incidence, reduced susceptibility to carcinogens and extended lifespan is analyzed. The potential role of the growth hormone/insulin-like growth factor type 1 (IGF-I) axis in this effect is discussed as is the evidence that a reduction in growth hormone and/or IGF-I leads to a reduction in spontaneous tumors and susceptibility to carcinogens.
Key words
Cancer - Aging - Insulin-like growth factor - Caloric restriction
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Ch. Sell
Lankenau Institute for Medical Research
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Phone: +01(610)645-8521
Fax: +01(610)645-2205
Email: sellc@mlhs.org