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Horm Metab Res 2003; 35(11/12): 734-739
DOI: 10.1055/s-2004-814155
Original
© Georg Thieme Verlag Stuttgart · New York

Subcellular Localization of IRS-1 in Cell Proliferation and Differentiation

X.  Tu1 , A.  Wu1 , A.  Maiorana1 , R.  Baserga1
  • 1 Kimmel Cancer Center, Thomas Jefferson University, Philadelphia
Further Information

Publication History

Received 13 August 2003

Accepted after Revision 7 October 2003

Publication Date:
07 January 2004 (online)

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Subcellular Localization of IRS-1 in Cell Proliferation and DifferentiationHorm Metab Res 2004; 36(01): 72
DOI: 10.1055/s-2004-814357

Abstract

The type 1 insulin-like growth factor receptor (IGF-IR) and its docking protein, insulin receptor substrate-1 (IRS-1), play important roles in cell transformation, cell differentiation and aging. IRS-1 and other IRS proteins can, under certain conditions, localize to the nuclei of cells, where they undergo interactions with nuclear and nucleolar proteins. In this study, we confirm and extend these observations, demonstrating that IRS-1 is preferentially nuclear in growing cells. Differentiation and inhibition of ribosomal RNA synthesis cause subcellular redistribution of IRS-1 and other nuclear proteins to the cytoplasm.

Key words

IGF-I receptor - Nuclear IRS-1 - Differentiation

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R. Baserga

Kimmel Cancer Center, Thomas Jefferson University

233 S. 10th Street · 624 BLSB · Philadelphia, PA 19107

Phone: +1(215)5034507

Fax: +1(215)9230249

Email: R_baserga@lac.tju.edu