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Horm Metab Res 2003; 35(11/12): 740-750
DOI: 10.1055/s-2004-814162
DOI: 10.1055/s-2004-814162
Review
© Georg Thieme Verlag Stuttgart · New York
The Insulin-like Growth Factor Axis in Cell Cycle Progression
J. Dupont1 , A. Pierre1 , P. Froment1 , C. Moreau1Further Information
Publication History
Received 26 August 2003
Accepted after Revision 25 September 2003
Publication Date:
07 January 2004 (online)
Abstract
Emerging evidence suggests that members of the Insulin-like Growth Factors (IGFs) family, including IGF-I, IGF-II, the IGF-I receptor (IGF-IR), and the IGF-binding proteins (IGFBPs) play a central role in the development and progression of cancer. Cancer cells exhibit an increased and deregulated proliferative activity. Abnormalities in many positive and negative modulators of the cell cycle are also frequent in many cancer types. Recent advances in the understanding of cell-cycle control mechanisms have been applied to outline the molecular mechanism through which IGFs regulate cell cycle progression. In this review, we will provide a brief overview of the role of the IGF system as a regulator of some components of the cell cycle.
Key words
Cancer - G1/S phase - IGF-IR - Signaling - Cell growth
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J. Dupont, Ph. D.
Unité de Physiologie de la Reproduction et des Comportements
Institut National de la Recherche Agronomique · Nouzilly 37 380 · France
Phone: + 33 (2) 47 42 79 64
Fax: + 33 (2) 47 42 77 43
Email: jdupont@tours.inra.fr