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Synlett 2004(3): 555-557
DOI: 10.1055/s-2004-815430
DOI: 10.1055/s-2004-815430
LETTER
© Georg Thieme Verlag Stuttgart · New York
In(OTf)3-Catalyzed Friedel-Crafts Reaction of Aromatic Compounds with Methyl Trifluoropyruvate in Water
Further Information
Received
5 November 2003
Publication Date:
26 January 2004 (online)
Publication History
Publication Date:
26 January 2004 (online)
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Abstract
In the presence of In(OTf)3 as a catalyst, aniline derivatives 1a-c, 1e-h and anisole derivatives 2a-c, 2e reacted with methyl trifluoropyruvate 3 in water at room temperature to give the corresponding Friedel-Crafts reaction products 4a-g and 5a-d in good yields, respectively.
Key words
In(OTf)3 catalyst - Friedel-Crafts reaction - methyl trifluoropyruvate - water - CF3-substituted compound
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