Subscribe to RSS
DOI: 10.1055/s-2004-815462
In Vitro Antimalarial Activity of Biflavonoids from Wikstroemia indica
This work was supported, in part, by funds from the UNDP/World Bank/WHO special Program for Research and Training in Tropical Disease (grant ID 990 806 and IDA10124), and Grants-in Aid for Scientific Research (A) from the Ministry of Education, Culture, Sports, Science and Technology, Japan. A part of work was supported by the 21st Century COE Program, Ministry of Education, Culture, Sports, Science and Technology (MEXT)Publication History
Received: June 13, 2003
Accepted: October 7, 2003
Publication Date:
06 February 2004 (online)
![](https://www.thieme-connect.de/media/plantamedica/200401/lookinside/thumbnails/10.1055-s-2004-815462-1.jpg)
Abstract
In our investigation of in vitro antimalarial screening of medicinal herbal extracts, the n-BuOH extract from the root of Wikstroemia indica showed a potent inhibitory effect. Fractionation of the active extract led to the isolation of two biflavonoids, sikokianin B (1) and sikokianin C (2) with IC50 values 0.54 μg/mL and 0.56 μg/mL, respectively, against the chloroquine-resistant strain of Plasmodium falciparum. This is the first report of the biological activity of 1 and 2. As the structure of l has remained unsettled, we confirmed the conformation by 1H- and 13C-NMR.
References
- 1 Niwa M, Jiang F P, Hirata Y. Two new C-3/C-3′′-biflavanones from Wikstroemia sikokiana . Chem Pharm Bull. 1986; 34 3631-4
- 2 Baba K, Taniguchi M, Kozawa M. Three biflavonoids from Wikstroemia sikokiana . Phytochemistry. 1994; 37 879-83
- 3 State Pharmaceutical A dministration. Zhonghua Bencao. Shanghai Science and Technology Press China; 1998
- 4 Otoguro K, Kohana A, Manabe C, Ishiyama A, Ui H, Shiomi K, Yamada H, Omura S. Potent antimalarial activities of polyether antibiotic, X-206. J Antibiotics. 2001; 54 658-63
Prof. Dr. H. Yamada
The Kitasato Institute for Life Sciences
Kitasato University
5-9-1 Shirokane
Minato-ku
Tokyo 108-8641
Japan
Phone: +81-3-3444-6161
Fax: +81-3-5791-6121
Email: yamada@lisci.kitasato-u.ac.jp