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Planta Med 2004; 70(1): 76-78
DOI: 10.1055/s-2004-815462
Letter
© Georg Thieme Verlag Stuttgart · New York

In Vitro Antimalarial Activity of Biflavonoids from Wikstroemia indica

Shinyu Nunome1 , Aki Ishiyama2 , Miyuki Kobayashi2 , Kazuhiko Otoguro2 , Hiroaki Kiyohara1 , Haruki Yamada1 , 2 , Satoshi Omura1 , 2
  • 1The Kitasato Institute for Life Sciences, Kitasato University, Tokyo, Japan
  • 2Research Center for Tropical Diseases, The Kitasato Institute, Tokyo, Japan
This work was supported, in part, by funds from the UNDP/World Bank/WHO special Program for Research and Training in Tropical Disease (grant ID 990 806 and IDA10124), and Grants-in Aid for Scientific Research (A) from the Ministry of Education, Culture, Sports, Science and Technology, Japan. A part of work was supported by the 21st Century COE Program, Ministry of Education, Culture, Sports, Science and Technology (MEXT)
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Publikationsverlauf

Received: June 13, 2003

Accepted: October 7, 2003

Publikationsdatum:
06. Februar 2004 (online)

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Abstract

In our investigation of in vitro antimalarial screening of medicinal herbal extracts, the n-BuOH extract from the root of Wikstroemia indica showed a potent inhibitory effect. Fractionation of the active extract led to the isolation of two biflavonoids, sikokianin B (1) and sikokianin C (2) with IC50 values 0.54 μg/mL and 0.56 μg/mL, respectively, against the chloroquine-resistant strain of Plasmodium falciparum. This is the first report of the biological activity of 1 and 2. As the structure of l has remained unsettled, we confirmed the conformation by 1H- and 13C-NMR.

References

  • 1 Niwa M, Jiang F P, Hirata Y. Two new C-3/C-3′′-biflavanones from Wikstroemia sikokiana .  Chem Pharm Bull. 1986;  34 3631-4
    PubMedSuche in Google Scholar
  • 2 Baba K, Taniguchi M, Kozawa M. Three biflavonoids from Wikstroemia sikokiana .  Phytochemistry. 1994;  37 879-83
    CrossrefPubMedSuche in Google Scholar
  • 3 State Pharmaceutical A dministration. Zhonghua Bencao. Shanghai Science and Technology Press China; 1998
    Suche in Google Scholar
  • 4 Otoguro K, Kohana A, Manabe C, Ishiyama A, Ui H, Shiomi K, Yamada H, Omura S. Potent antimalarial activities of polyether antibiotic, X-206.  J Antibiotics. 2001;  54 658-63
    PubMedSuche in Google Scholar

Prof. Dr. H. Yamada

The Kitasato Institute for Life Sciences

Kitasato University

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eMail: yamada@lisci.kitasato-u.ac.jp