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Synthesis 2004(6): 861-864
DOI: 10.1055/s-2004-815991
DOI: 10.1055/s-2004-815991
PAPER
© Georg Thieme Verlag Stuttgart · New York
Simple One-Pot Three-Component Synthesis of 2-Oxo-1,11b-dihydro-2H-pyrimido[2,1-a]isoquinolines
Weitere Informationen
Received
20 January 2004
Publikationsdatum:
25. Februar 2004 (online)
Publikationsverlauf
Publikationsdatum:
25. Februar 2004 (online)
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Abstract
Isoquinoline reacts smoothly with dialkyl acetylenedicarboxylates in the presence of isocyanates to produce dialkyl 2-oxo-1,11b-dihydro-2H-pyrimido[2,1-a]isoquinoline-3,4-dicarboxylates in good yields.
Key words
isocyanates - cyclizations - heterocycles - quinolines - isoquinolines - alkynes
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