Simple One-Pot Three-Component Synthesis of 2-Oxo-1,11b-dihydro-2H-pyrimido[2,1-a]isoquinolines

Mehdi Adib; Mehdi Mollahosseini; Hossine Yavari; Mohammad Hosein Sayahi; Hamid Reza Bijanzadeh

doi:10.1055/s-2004-815991

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Simple One-Pot Three-Component Synthesis of 2-Oxo-1,11b-dihydro-2H-pyrimido[2,1-a]isoquinolines

Mehdi Adib*^a, Mehdi Mollahosseini^a, Hossine Yavari^a, Mohammad Hosein Sayahi^a, Hamid Reza Bijanzadeh^b
^a Department of Chemistry, Faculty of Science, University of Tehran, Tehran, Iran
Fax: +98(21)6495291; e-Mail: madib@khayam.ut.ac.ir;
^b Department of Chemistry, University of Tarbiat Modarres, Tehran, Iran

Abstract

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Abstract

Isoquinoline reacts smoothly with dialkyl acetylenedicarboxylates in the presence of isocyanates to produce dialkyl 2-oxo-1,11b-dihydro-2H-pyrimido[2,1-a]isoquinoline-3,4-dicarboxylates in good yields.

Key words

isocyanates - cyclizations - heterocycles - quinolines - isoquinolines - alkynes

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References

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