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Synthesis 2004(6): 861-864  
DOI: 10.1055/s-2004-815991
PAPER
© Georg Thieme Verlag Stuttgart · New York

Simple One-Pot Three-Component Synthesis of 2-Oxo-1,11b-dihydro-2H-pyrimido[2,1-a]isoquinolines

Mehdi Adib*a, Mehdi Mollahosseinia, Hossine Yavaria, Mohammad Hosein Sayahia, Hamid Reza Bijanzadehb
a Department of Chemistry, Faculty of Science, University of Tehran, Tehran, Iran
Fax: +98(21)6495291; e-Mail: madib@khayam.ut.ac.ir;
b Department of Chemistry, University of Tarbiat Modarres, Tehran, Iran
Further Information

Publication History

Received 20 January 2004
Publication Date:
25 February 2004 (online)

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Abstract

Isoquinoline reacts smoothly with dialkyl acetylenedicarboxylates in the presence of isocyanates to produce dialkyl 2-oxo-1,11b-dihydro-2H-pyrimido[2,1-a]isoquinoline-3,4-dicarboxylates in good yields.

Key words

isocyanates - cyclizations - heterocycles - quinolines - isoquinolines - alkynes

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