Synlett 2004(5): 0871-0873  
DOI: 10.1055/s-2004-820025
LETTER
© Georg Thieme Verlag Stuttgart · New York

A Clean One-pot Synthesis of Tetrahydrobenzo[b]pyran Derivatives Catalyzed by Hexadecyltrimethyl Ammonium Bromide in Aqueous Media

Tong-Shou Jin*, Ai-Qing Wang, Xin Wang, Jian-She Zhang, Tong-Shuang Li
Department of Chemistry, College of Chemistry and Environmental Science, Hebei University, Baoding 071002, P. R. China
Fax: +86(312)5079361; e-Mail: orgsyn@mail.hbu.edu.cn;
Weitere Informationen

Publikationsverlauf

Received 9 January 2004
Publikationsdatum:
04. März 2004 (online)

Zoom Image

Abstract

An efficient and convenient approach to the synthesis of 2-amino-3-cyano-4-aryl-7,7-dimethyl-5-oxo-4H-5,6,7,8-tetra­hydrobenzo[b]pyran derivatives using hexadecyltrimethyl ammonium bromide (HTMAB) as the catalyst (10 mol%) is described. This method provides several advantages such as neutral conditions, high yields and simple work-up procedure, in addition water was chosen as a green solvent.