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Synlett 2004(6): 1095-1097  
DOI: 10.1055/s-2004-820059
LETTER
© Georg Thieme Verlag Stuttgart · New York

A Simple Copper Salt Catalyzed N-Arylation of Amines, Amides, Imides, and Sulfonamides with Arylboronic Acids

Jing-Bo Lana, Guo-Lin Zhangb, Xiao-Qi Yu*a, Jing-Song Youa, Li Chena, Mei Yana, Ru-Gang Xie*a
a Department of Chemistry, Sichuan University, Chengdu 610064, P. R. China
b Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu 610041, P. R. China
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Publication History

Received 16 February 2004
Publication Date:
25 March 2004 (online)

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Abstract

A simple copper salt catalyzed N-arylation reaction with arylboronic acids is reported. In the presence of a catalytic amount of a simple copper salt, the coupling of arylboronic acids with imides was performed in MeOH to give N-arylimides in excellent yields; a variety of amines, amides and sulfonamides could also be successfully coupled with arylboronic acids to give corresponding N-arylated products in moderate yields.

Key words

N-arylation - copper salt - boronic acid - coupling - Ullmann reaction