Hydroxyapatite Cement (HAC) to Repair Cortical Defects in Long Bones - An Animal Study

E. Schwendenwein; S. Hajdu; G. Kaltenecker; C. Gäbler; I. László; S. Lang; P. Roschger; R. Wintersteiger; V. Vécsei

doi:10.1055/s-2004-822598

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Osteosynthesis and Trauma Care 2004; 12(1): 20-24
DOI: 10.1055/s-2004-822598

Original Article

Hydroxyapatite Cement (HAC) to Repair Cortical Defects in Long Bones - An Animal Study

E. Schwendenwein¹ , S. Hajdu¹ , G. Kaltenecker¹ , C. Gäbler¹ , I. László² , S. Lang³ , P. Roschger⁴ , R. Wintersteiger⁵ , V. Vécsei¹

¹Department of Traumatology, University of Vienna Medical School, Vienna, Austria
²Department of Orthopaedics and Traumatology, University of Targu-Mures Medical School, Targu-Mures, Romania
³Clinical Institute of Clinical Pathology, University of Vienna Medical School, Vienna, Austria
⁴Ludwig Boltzmann-Institute of Osteology in Hanusch Hospital and Trauma Centre Meidling, Vienna, Austria
⁵Department of Pharmacy, University of Graz, Chemistry, Graz, Austria

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Publication History

Publication Date:
30 March 2004 (online)

Abstract
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Abstract

Hydroxyapatite cement (HAC) paste has already been used in animal experiments as well as in clinical studies on the cranial skeleton, i. e., on non-stressed bone, for the reconstruction of defects. The present experiment intended to provide information if HAC can be applied for treatment of defects in the stressed cortical region of long bones. For this purpose artificial defects were set on the ulnar diaphyses of six New Zealand rabbits and filled with HAC plugs. After set periods of time (postoperative, 8 days, 12 days, 4 weeks, 4 months) the results were clinically, radiologically, histologically and electron microscopically evaluated. No complications occurred in the animal study group. The results showed that HAC can be successfully applied as an excellent bio-compatible material to the stressed cortical region of long bones for the repair of stable bone defects. After four months bone tissue of full value was shown to be present when examined with both light and under electron microscopes. HAC was resorbed completely within this time period.

Key words

Hydroxyapatite cement - defect repair - cortical long bones - rabbit

References

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E. SchwendenweinM.D.

Department of Traumatology

University of Vienna Medical School

Währinger Gürtel 18-20

1090 Vienna

Austria

Phone: +43/1-4 04 00-59 41

Fax: +43/1-4 04 00-59 39

Email: elisabeth.schwendenwein@akh-wien.ac.at